UNDERSTANDING RESILIENCE

Understanding Resilience

Resilience is the ability to adapt successfully in the face of stress and adversity.Stressful life events, trauma and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of PTSD, depression and other psychiatric disorders.However, most individuals do not develop such illnesses after exp

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Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias

IntroductionSchizophrenia (SCZ) is a complex neurodevelopmental disorder characterised by functional and structural brain dysconnectivity and disturbances in perception, cognition, emotion, and social functioning.In the present study, we investigated whether the microstructural organisation of the uncinate fasciculus (UF) was associated with emotio

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Control of endothelial tubulogenesis by Rab and Ral GTPases, and apical targeting of caveolin-1-labeled vacuoles.

Here, we examine known GTPase regulators of vesicle trafficking events to assess whether they affect endothelial cell (EC) lumen and tube formation.We identify novel roles for the small GTPases Rab3A, Rab3B, Rab8A, Rab11A, Rab27A, RalA, RalB and caveolin-1 in co-regulating membrane trafficking events that control EC lumen and tube formation.siRNA s

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